High Quality Undenatured Collagen Type II for Joint Health

 

1. Cartilage

Cartilage is a matrix composed mainly of collagens and proteoglycan aggregates. The main cartilage collagen is Collagen Type II. The cartilage proteoglycan aggregates consist of a long spine of hyaluronic acid and many proteoglycan monomers non-covalently bound to the hyaluronic acid spine through two linker proteins. Proteoglycans are composed of long glycosaminoglycan (GAG) chains covalently linked to a core protein. The linker proteins bind to both the core protein of the proteoglycan and to the hyaluronic acid chain, thereby stabilizing the aggregate. GAG has long unbranched chains composed of repeating disaccharide units. One of the two sugars is always an amino sugar, either N-acetyl-D-glucosamine or N-acetyl-D-galactosamine. In cartilage, GAGs are mainly chondroitin sulfate and keratan sulfate.

Glucosamine exists in the form of N-acetyl D-glucosamine, which is an important component of GAG.

2. Collagens

 

Collagen is a triple helix of polypeptide chains. Each polypeptide chain usually has about 1000 amino acids. Analysis of the polypeptide chains reveals that glycine and proline or hydroxyproproline are very prominent. Almost one third of the amino acids are glycine and one quarter is proline or hydroxyproline. Most of the polypeptide chain is a repeating unit of the tripeptide glycine-X-proline, where X is another amino acid and proline can be hydroxyproline.

The polypeptides assume a left-handed helix conformation. This structure enables the 3 helices to interlock better to form a rigid 3-stranded cable or triple helix.

There are fourteen types of known collagens in our body. The most important ones are Types I, II, III and IV. Types I & III coexist in skin. In cartilage, Type II is predominant. However, the ratio of Type II Collagen to other collagens differs in different types of cartilage.

3. Collagen Type II for Joint Health

 

Collagen Type II is made from chicken sternum and contains all the important components of cartilage: collagens and GAGs (chondroitin, hyaluronic acid and keratan). Type II collagen accounts for 90-95% of all collagen in sternum cartilage, which is very similar to the compositions of collagen in human joint cartilage. As we age, the body's ability to make collagen proteins and GAGs slows down.

Supplying building blocks of cartilage for joint health has been shown to be effective in numerous studies. Glucosamine and chondroitin are examples of such successful supplements. Thus, collagen may provide additional benefits to joint health.

Chondroitin is only one piece of the puzzle. Supplementing with Collagen Type II, which contains all the cartilage-building components (including Collagen Type II and GAGs) and cartilage stimulating elements, provides the complete cartilage solution.

4. Source for Collagen Type II

The most cost effective source of Collagen Type II is young chicken sternum cartilage. In sternum, the predominant collagen is Type II (over 90% of the sternum collagen). The content of total protein (mainly collagen) is over 25%. The rest is mainly chondroitin, hyaluronic acid, and keratan.

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About us

Vanz Pharm, which is specialized in custom synthesis and R&D in APIs and pharmaceutical intermediates, is located in Wuhan, China. We have established long-term cooperation with Shanghai Institute of Organic Chemistry, Wuhan University etc since 2011. 

  

As a special team in organic chemistry and medical chemistry, we also support the technology of R&D on new product. We have strong advantages on the process research and product R&D, pay attention to researching and developing new technology which is self-owned intellectual property right. We are special at developing Drug for the respiratory, antidepressant, antivirus, etc. We have completed R&D of more than 20 APIs and intermediates after the company founded.