| Product Name: | OPIORPHIN |
| Synonyms: | OPIORPHIN;H-Gln-Arg-Phe-Ser-Arg-OH;L-Arginine,L-glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-;L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine;opiorphin H-6504 |
| CAS: | 864084-88-8 |
| MF: | C29H48N12O8 |
| MW: | 692.77 |
Application:
Details : Opiorphin is a penta-peptide (Gln-Arg-Phe-Ser-Arg) which has similar analgesic efficacy to mo -rphine with fewer side effects in rats . It is a dual endogenous ectopeptidase en kephalinase inhibitor ; inhibits both neutral endopeptidase (NEP) and amino-peptidase N (AP-N)
Opiorphin pentapeptide originates from the N-terminal region of the protein PROL1 (proline-rich, lacrimal 1). Opiorphin inhibits three pro teases : neutral ecto-endopeptidase ( MME ), ecto-aminopeptidase N ( ANPEP ) and perhaps also a dipeptidyl peptidase DPP3. Such action extends the duration of kephalin effect where the natural pain killers are released physiologically in response to specific potentially painful stimuli, in contrast with administration of narcotics, which floods the entire body and causes many undesirable adverse reactions, including addiction liability and constipation. In addition, opiorphin may exert anti-depressive and antipanic action.
Therapeutic application of opiorphin in humans would require modifying the molecule to avoid its rapid degradation in the intestine and its poor penetration of the blood-brain barrier . [11] [12] This modification is done in the body by transformation of N-terminal glutamine into pyroglutamate. This form preserves the analgesic properties of opiorphin but with increased pharmaceutical stability.
| Nicotinamide Riboside Chloride(NRC) | 23111-00-4 | 98.0% |
| Beta-Nicotinamide Mononucleotide(NMN) | 1094-61-7 | 99.0% |
| β-Nicotinamide Adenine Dinucleotide(NAD+) | 53-84-9 | 99.0% |
| Olivetol(3,5-hydroxypentylbenzene) | 500-66-3 | 99.0% |
| Compound 7P | 1890208-58-8 | 98.0% |
| Noopept,GVS-111 | 157115-85-0 | 99.5% |
| Piracetam | 7491-74-9 | 99.0% |
| Aniracetam | 72432-10-1 | 99.0% |
| Nefiracetam | 77191-36-7 | 99.0% |
| Pramiracetam | 68497-62-1 | 99.0% |
| Fasoracetam | 110958-19-5 | 99.0% |
| Sunifiram | 314728-85-3 | 99.5% |
| Coluracetam | 135463-81-9 | 99.0% |
| Alpha GPC(Choline Alfoscerate) | 28319-77-9 | 99.0% |
| Alpha GPC(Choline Alfoscerate) | 28319-77-9 | 50.0% |
| Citicoline | 987-78-0 | 99.0% |
| Galantamine Hydrobromide | 69353-21-5 | 98.0% |
| PRL-8-53 | 51352-87-5 | 99.0% |
| NSI-189 Phosphate | 1270138-41-4 | 99.0% |
| NSI-189 | 1270138-40-3 | 99.0% |
| Tianeptine | 66981-73-5 | 99.0% |
| Tianeptine sodium | 30123-17-2 | 99.0% |
| Tianeptine hemisulfate monohydrate (THM) | 1224690-84-9 | 99.0% |
| Agomelatine | 138112-76-2 | 99.0% |
FAQ
Q1. How to confirm the Product Quality before placing orders?
A. Offering you our products specification standard (tested by HPLC, UV, GC and TLC etc.)
B. Free samples could be sent to check the product quality before ordering.
C. If you have special requirement on the product, we may customize it according to your requirement until to your approval.
Q2: Samples & MOQ
A. We could provide some free samples, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier
to collect the samples.
B. For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 1kg.
Q3: How about delivery?
A: Delivery lead time: within 1-2 days when get the payment.
B. Samples: please expect 5-7 days by FedEx,EMS, UPS,TNT..
C.Double customs clearance ,safe delivery ,gurantee receive.