99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6

Model NO.
Terbinafine
Transport Package
Bag
Trademark
vanz
Origin
China
HS Code
2942000000
Production Capacity
100kg/Month
Reference Price
Please contact us for quote
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Product Description

What is  Terbinafine hydrochloride?
 
 
Terbinafine hydrochloride 78628-80-5 a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.
Terbinafine·HCl 78628-80-5 a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. 
Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis.
Additionally, Terbinafine 78628-80-5 has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed.


 
CAS 78628-80-5
Appearance white crystalline powder
Molecular formula C21H26CIN
Molecular Weight 327.89
Assay 98%
Shelf Life 24 months when properly stored
Storage Keep in a cool, dry, dark location

 


 

Function of Terbinafine hydrochloride


Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion ofsqualene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis.

Application of Terbinafine hydrochloride


1. Terbinafine hydrochloride is mainly effective on the dermatophyte group of fungi.

2. As a 1% cream or powder, Terbinafine hydrochloride is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.

3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have been studied.

4.Terbinafine HCLmay induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.


 

99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6

99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6 99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6


99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6 99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6




99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6




99% Purity Terbinafine Hydrochloride Powder CAS 91161-71-6




 

Q1:Are you a manufacturer?
A:Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity andcustomer synthesis products in our lab located in Wuhan.
Q2:Do you have stock?
  A:We understand most customers prefer stock, so we'll try to keep stock for most products.However, for some rare products, we won't keep stock and it needs time to synthesize.
 

Q3:What certificates and documents do you offer?
A:Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
 
Q4:Why should I choose you?
  A:Powerful technical support-come from our highly skilled & fully experienced staff, working in chem
ical industry for over 5 years, in average.Strict quality control-comes form our sophisticated manage
ment system.Professional and warm sales team-since we believe we can only win via our hard work
in a competitive world Quick response and excellent presale and after sale service-since we believe
our customers deserve all the best service.
 
Q5:How should I pay?
A:We accept all kinds of payment ways.Such as  T/T, West union, MoneyGram,L/C.

 

Pharmaceutical Intermediate

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