65899-73-2 Vagistat Antibacterial Hot Sale, High Quality and Best Price, Safety Transport, Discount Is Here!

Model NO.
65899-73-2 Vagistat
Quality
High Quality
Quality Requirement
Strictly Quality Control
Standard
USP/Ep/Bp/Cp/IP/Jp/Who/in-House
Capacity
1000kg/Mon
Transport Package
25kg/Drum/1000g/Bag/10g/Bag
Specification
100% raw material
Trademark
Widely
Origin
China
Production Capacity
1000kg/Mon
Reference Price
$ 13.50 - 45.00
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Product Description

65899-73-2 Vagistat Antibacterial Hot Sale, High Quality and Best Price, Safety Transport, Discount Is Here!
65899-73-2
Antibacterial
Vagistat
CAS:65899-73-2
MF:C16H13Cl3N2OS
MW:387.71
EINECS:265-973-8
MDL No.:MFCD00057276

Tioconazole is a substituted imidazole derivative, structurally related to econazole, clotrimazole, and miconazole, with the chemical name 1-[2,4-dichloro-b-[(2-chloro-3-thenyl)oxy]-phenethyl]imidazole; the chemical formula is C16H13Cl3N2OS and the molecular structure is shown below. It has a broad spectrum of antifungal activity including pathogenic yeasts, dermatophytes, and Aspergillus spp., as well as Trichomonas vaginalis. Tioconazole is marketed as a topical formulation for the treatment of superficial dermatophyte infections and vaginal candidiasis. It is available without prescription in some countries.



Mechanism of action  
In a similar manner to the other imidazole agents, tioconazole inhibits sterol biosynthesis by the inhibition of cytochrome P450-dependent C-14a-demethylation of lanosterol, preventing conversion to ergosterol, which results in depletion of normal fungal sterols (ergosterol) and accumulation of 14a-methyl sterols (lanosterol) in the fungal cell membrane. This inhibition is thought to produce fungistatic activity. At higher concentrations, tioconazole appears to produce direct cell membrane damage, resulting in leakage of essential intracellular components and cell death. Fungicidal activity has been demonstrated during stationary phases of growth in Candida spp. which supports the hypothesis of direct cell membrane damage.



Chinese factory quality, spot delivery on the same day, express delivery in five days


Storage: keep away from light, sealed and stored in a cool and dry place


 

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LEGALIS.IT, 2023